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Risk Factors and the Impact of Multidrug-Resistant Bacteria on Community-Acquired Urinary Sepsis

Manuel Madrazo1, Ian López-Cruz1, Laura Piles1

  • 1Hospital Universitario Doctor Peset, 46017 Valencia, Spain.

Microorganisms
|June 15, 2023
PubMed

Insights

This study identified healthcare-associated urinary sepsis (US) as a key risk factor for multidrug-resistant bacteria (MDRB) in community-acquired US. While MDRB did not worsen hospital mortality, it showed a trend toward longer hospital stays.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Urology

Background:

  • Multidrug-resistant bacteria (MDRB) are a growing concern in healthcare settings.
  • Risk factors and outcomes for community-acquired urinary sepsis (US) due to MDRB remain understudied.
  • Understanding these factors is crucial for effective patient management and infection control.

Purpose of the Study:

  • To identify independent risk factors for MDRB in community-acquired US.
  • To evaluate the influence of MDRB on patient outcomes, including mortality and length of hospital stay.
  • To compare clinical characteristics and outcomes between MDRB and non-MDRB US cases.

Main Methods:

  • Prospective observational study involving 193 patients with community-acquired US admitted to a university hospital.
  • Comparison of epidemiological and clinical variables and outcomes between patients with MDRB and non-MDRB US.
  • Logistic regression analysis to determine independent risk factors for MDRB.

Main Results:

  • 33.7% of patients had US caused by MDRB, with a median age of 82 years.
  • Hospital mortality was 17.6% and did not differ significantly between MDRB and non-MDRB groups.
  • Healthcare-associated US was identified as an independent risk factor for MDRB; a non-significant trend towards longer hospital stays was observed in the MDRB group.

Conclusions:

  • The impact of MDRB on outcomes in community-acquired urinary sepsis was found to be mild.
  • Healthcare-associated urinary sepsis is a significant independent risk factor for developing MDRB infections.
  • Further research may be needed to explore optimal management strategies for MDRB in this patient population.
Keywords:
multidrug-resistant bacteria (MDRB)nosocomial urinary tract infection (UTI)risk factors

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