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Granular Hydrogels in Biofabrication: Recent Advances and Future Perspectives.
1Biomedical Engineering, University of Galway, Galway, H91 TK33, Ireland.
Advanced Healthcare Materials
|June 15, 2023
Summary
Granular hydrogels offer tunable properties for bioprinting. This review explores their design, fabrication, and impact on cell behavior, guiding future bioink development.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Rheology
Background:
- Granular hydrogels, composed of packed microgels, present unique properties like extrudability and modularity for bioprinting.
- Optimizing granular hydrogel design is complex due to numerous interacting parameters influencing printability and cell behavior.
Purpose of the Study:
- To review granular hydrogel fabrication methods.
- To analyze how design parameters affect printability and cellular responses.
- To discuss applications in bioink engineering and future directions.
Main Methods:
- Literature review of granular hydrogel fabrication.
- Analysis of structure-property relationships in granular hydrogels.
- Examination of cellular responses to granular hydrogel properties.
Main Results:
- Design inputs significantly influence rheological properties critical for bioprinting.
- Granular hydrogel properties impact cell behavior and tissue maturation post-printing.
- Granular design principles enhance bioink development and support embedded printing.
Conclusions:
- Granular hydrogels provide a versatile platform for advanced bioprinting applications.
- Understanding design-property-function relationships is key to optimizing granular hydrogels for tissue engineering.
- Future research should focus on further refining granular hydrogel design for enhanced cell and tissue development.
