Related Experiment Video
Updated: Jul 26, 2025

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
Insulin resistance is associated with cognitive dysfunction in multiple sclerosis patients: A cross-sectional study
Hormoz Ayromlou1, Samaneh Hosseini1, Mohammad Khalili2
1Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Multiple sclerosis patients with insulin resistance show significant cognitive decline, particularly in verbal memory and spatial comprehension. This highlights the link between metabolic health and neurological function in MS.
Area of Science:
- Neuroscience
- Endocrinology
- Metabolic Syndrome
Background:
- Multiple sclerosis (MS) is a neurodegenerative disease impacting cognitive functions.
- Impaired glucose and insulin metabolism can worsen cognitive decline in MS patients.
Purpose of the Study:
- To compare cognitive function in relapsing-remitting MS patients with and without insulin resistance.
- To investigate the association between insulin resistance indicators and cognitive performance.
Main Methods:
- Cross-sectional study of 74 relapsing-remitting MS patients.
- Assessment of insulin resistance using fasting blood glucose, insulin levels, and HOMA-IR index.
- Cognitive evaluation using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) battery.
Main Results:
- Prevalence of insulin resistance was 37.8%; cognitive decline was 67.56%.
- MS patients with insulin resistance scored significantly lower on verbal learning, delayed recall, word association, and spatial comprehension tests.
- Negative correlations observed between cognitive test scores (CVLT, BVMT, DELIS-Kaplan) and fasting insulin levels.
Conclusions:
- Insulin resistance is linked to greater cognitive impairments in MS patients.
- Verbal memory and spatial comprehension are particularly affected in MS patients with insulin resistance.
- Metabolic health, specifically insulin sensitivity, may be a critical factor in managing cognitive function in MS.
More Related Videos
08:32Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
08:47Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
Published on: December 7, 2017
Related Concept Videos
Psychoneuroimmunology: Diabetes and Cancer
Oral Hypoglycemic Agents: Biguanides and Glitazones
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational