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Updated: Jul 26, 2025
08:18
Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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Increased cell senescence in human metabolic disorders
Rosa Spinelli1,2,3, Ritesh Kumar Baboota1,4, Silvia Gogg1
1Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
The Journal of Clinical Investigation
|June 15, 2023
Summary
Cell senescence, a hallmark of aging, also drives metabolic disorders like obesity and type 2 diabetes. Therapies targeting senescent cells may offer new treatment avenues for these conditions.
Area of Science:
- Metabolic disorders
- Cellular senescence
- Aging research
Background:
- Cellular senescence (CS) increases with aging and in metabolic diseases like obesity and type 2 diabetes (T2D).
- Senescent tissues exhibit cellular dysfunction and inflammation, affecting various cell types.
- Hyperinsulinemia and insulin resistance (IR) are linked to increased CS in adipose and liver cells.
Purpose of the Study:
- To investigate the role of cellular senescence in metabolic disorders.
- To explore the relationship between insulin resistance and cellular senescence.
- To evaluate the potential of senomorphic/senolytic therapies for metabolic diseases.
Main Methods:
- Analysis of cell senescence markers in metabolic tissues.
- Investigation of hyperinsulinemia and insulin resistance effects on cell senescence.
- Assessment of cellular senescence impact on insulin resistance.
Main Results:
- Cellular senescence is elevated in obesity, T2D, and nonalcoholic fatty liver disease, independent of age.
- Hyperinsulinemia and insulin resistance promote cellular senescence.
- Cellular senescence exacerbates insulin resistance, demonstrating a bidirectional relationship.
- Increased adipose tissue senescence in T2D suggests premature aging.
Conclusions:
- Cellular senescence is a key factor in metabolic disorders, beyond its role in aging.
- The interdependence of CS and IR highlights a critical pathway in metabolic dysfunction.
- Senomorphic and senolytic therapies show promise for treating common metabolic disorders.
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