Multipurpose Broadband NMR Inversion Sequences.

Area of Science:

• Chemistry
• Spectroscopy
• Physical Chemistry

Background:

• 2D correlation NMR experiments enhance signal-to-noise, resolution, and molecular connectivity insights.
• Broad chemical shift ranges in nuclei can compromise NMR experiments, leading to artifacts and signal loss.

Purpose of the Study:

• To introduce a general broadband strategy for high-performing NMR experiments.
• To overcome limitations in NMR spectroscopy caused by broad chemical shift ranges.

Main Methods:

• Development of a general broadband strategy by modifying delays in pulse blocks.
• Replacing inversion elements in NMR experiments with a versatile pulse block.
• Achieving arbitrary and independent evolution of NMR interactions.

Main Results:

• The new strategy significantly improves experimental bandwidth by an order of magnitude.
• The enhanced bandwidth covers chemical shift ranges of most molecules, even at ultrahigh fields.
• Enables robust spectroscopy for challenging molecules like perfluorinated oils and fluorophosphorous compounds.

Conclusions:

• The developed broadband NMR strategy provides a library of high-performing experiments.
• This approach broadens the applicability of NMR spectroscopy to a wider range of molecules.
• Facilitates advanced analysis of complex chemical systems, including those in battery electrolytes.