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Updated: Jul 26, 2025
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
Current status and research progress of nanoparticle application in superficial fungal infection
1Department of Graduate School, Bengbu Medical College, Bengbu, China. txhtxh@sina.com.
Abstract:
Superficial fungal infections (SFIs) are characterized by diverse etiologies, complex pathogenesis, and marked geographical differences in patient symptoms. Conventional management of SFIs is associated with complications such as hepatotoxicity, skin problems, severe headaches, and clinical difficulties including intractable relapses and drug-drug interactions in patients with chronic diseases remain to be addressed. Moreover, in topical treatment, low penetration of antifungal drugs in hard tissues such as finger (toe) nails and drug-resistant fungi are emerging concerns in current antifungal therapy. Nanotechnology has been a leading research topic in recent years for new dosing forms of antifungal drugs, chemical modification of traditional drugs, and pharmacokinetic improvement, providing potential opportunities for the effective treatment of SFIs. The present study reviewed the direct use of nanoparticles in SFIs and the use of nanoparticles as carriers in SFIs and discussed their future medicinal applications.
Insights
Nanotechnology offers promising solutions for superficial fungal infections (SFIs). This review explores nanoparticles for direct use and drug delivery, addressing challenges in conventional antifungal therapy.
Area of Science:
- Mycology
- Nanomedicine
- Dermatology
Background:
- Superficial fungal infections (SFIs) present diverse challenges, including varied causes, complex development, and geographical symptom differences.
- Conventional treatments for SFIs risk side effects like liver damage and drug interactions, with issues like persistent relapses and poor drug penetration into nails.
- Emerging concerns include drug-resistant fungi and the limited efficacy of topical antifungals on hard tissues like nails.
Purpose of the Study:
- To review the application of nanotechnology in treating superficial fungal infections.
- To explore the direct use of nanoparticles and their role as carriers for antifungal drugs.
- To discuss the future potential of nanomedicine in managing SFIs.
Main Methods:
- Literature review of studies on nanoparticles in superficial fungal infections.
- Analysis of direct nanoparticle applications in SFI treatment.
- Evaluation of nanoparticles as drug delivery systems for antifungal agents.
Main Results:
- Nanoparticles show potential for improved antifungal drug delivery and efficacy.
- Direct use of nanoparticles offers new therapeutic avenues for SFIs.
- Nanotechnology can enhance pharmacokinetic properties of antifungal drugs.
Conclusions:
- Nanotechnology presents a significant opportunity for advancing superficial fungal infection treatment.
- Nanoparticle-based strategies can overcome limitations of current antifungal therapies.
- Further research into nanomedicine holds promise for effective SFI management.
