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The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with

Ahmad R Al-Qudimat1,2, Ayisha Ameen3, Doaa M Sabir3

  • 1Surgical Research Section, Department of Surgery, Hamad Medical Corporation, Doha, Qatar. aalqudimat@hamad.qa.

Journal of Epidemiology and Global Health
|June 15, 2023
PubMed

Insights

Hypertension is linked to increased COVID-19 mortality, but other factors like comorbidities and age also significantly raise death risks. This review highlights the complex interplay of risk factors in COVID-19 outcomes.

Area of Science:

  • Public Health
  • Epidemiology
  • Internal Medicine

Background:

  • The COVID-19 pandemic has seen numerous studies on risk factors for mortality.
  • Hypertension (HTN) is a common comorbidity, and its association with COVID-19 mortality requires comprehensive updates.

Approach:

  • A systematic review and meta-analysis were conducted following PRISMA guidelines.
  • Searches were performed on PubMed, Scopus, and Cochrane databases for studies published between December 2019 and August 2022.
  • 23 observational studies with over 611,000 patients were included.

Key Points:

  • The overall mortality prevalence in the included studies was 0.5% (3119 deaths out of 611,522 patients).
  • Pooled mortality rates varied significantly across studies.
  • Subgroup analyses indicated that male patients with hypertension had a slightly lower mortality risk compared to female patients, particularly when men constituted over 50% of the cohort.

Conclusions:

  • Hypertension is a significant risk factor for COVID-19 mortality.
  • However, it is not the sole determinant; other comorbidities and advanced age substantially increase mortality risk.
  • Further research into the multifactorial nature of COVID-19 mortality is warranted.
Abstract

Keywords:
COVID-19Chronic diseaseHTNMortalityPandemicPrevalence

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