The function of long non-coding RNA SNHG11 and its working mechanism in triple-negative breast cancer

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Triple-negative breast cancer (TNBC) poses a significant health challenge for women.
• The molecular mechanisms underlying TNBC progression require further elucidation.

Purpose of the Study:

• To investigate the role and mechanism of long non-coding RNA (lncRNA) SNHG11 in TNBC.
• To explore the regulatory network involving SNHG11, microRNA-7-5p (miR-7-5p), specificity protein 2 (SP2), and mucin 1 (MUC-1) in TNBC.

Main Methods:

• Detection of SNHG11, miR-7-5p, SP2, and MUC-1 expression in TNBC tissues and cells.
• Evaluation of the impact of SNHG11 and SP2 on TNBC cell malignant behaviors.
• Prediction and verification of molecular interactions using bioinformatics and experimental approaches.
• Analysis of SP2 binding to the MUC-1 promoter.

Main Results:

• Elevated expression of SNHG11, SP2, and MUC-1 was observed in TNBC.
• SNHG11 knockdown inhibited TNBC cell progression.
• SP2 silencing attenuated the promoting effect of SNHG11 on TNBC.
• SNHG11 negatively regulated miR-7-5p and positively regulated SP2.
• SP2 directly bound to the MUC-1 promoter, suppressing MUC-1 expression.

Conclusions:

• lncRNA SNHG11 promotes TNBC cell malignant behaviors and facilitates tumor progression.
• The SNHG11/miR-7-5p/SP2/MUC-1 axis represents a novel regulatory pathway in TNBC.
• SNHG11 holds potential as a therapeutic target for TNBC.