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Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
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Coronary microvascular dysfunction and cardiovascular disease: Pathogenesis, associations and treatment strategies

Zhihua Yang1, Yangxi Liu2, Zhenzhen Li3

  • 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 15, 2023
PubMed

Insights

Coronary microvascular dysfunction (CMD) is a significant risk factor for cardiovascular events. This review explores CMD

Area of Science:

  • Cardiology
  • Vascular Biology
  • Pathophysiology

Background:

  • Coronary microvascular dysfunction (CMD) is a critical risk factor for cardiovascular events, yet its mechanisms remain poorly understood.
  • CMD is linked to various cardiovascular diseases, exacerbating their progression and negatively impacting patient prognosis.
  • Limited understanding of CMD's complex etiology and hidden nature hinders effective clinical diagnosis and treatment strategies.

Purpose of the Study:

  • To review the pathogenesis and functional assessment of Coronary Microvascular Dysfunction (CMD).
  • To elucidate the relationship between CMD and cardiovascular diseases.
  • To summarize current and future therapeutic strategies for CMD and associated cardiovascular diseases.

Main Methods:

  • Literature review of pathogenesis and functional assessment of CMD.
  • Analysis of studies linking CMD to cardiovascular diseases.
  • Synthesis of recent treatment strategies for CMD and cardiovascular diseases.

Main Results:

  • CMD's pathogenesis and functional assessment are complex and not fully understood.
  • CMD significantly contributes to the development and progression of cardiovascular diseases.
  • Current research highlights the need for improved therapeutic strategies targeting coronary microvascular remodelling and myocardial perfusion.

Conclusions:

  • CMD is a crucial factor in cardiovascular disease development and prognosis.
  • Further research into CMD's pathophysiology is essential for improved clinical outcomes.
  • Targeting coronary microvascular remodelling and myocardial perfusion offers promising therapeutic avenues for cardiovascular diseases.

Keywords:
Cardiovascular diseaseCoronary flow reserveCoronary microvascular dysfunctionIndex of microcirculatory resistancePathogenesisTreatment strategies

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