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Related Experiment Video

Updated: Jul 26, 2025

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
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Oncogeriatric Developments.

Martine Extermann1, Mohammed Al-Jumayli1, Christine Sam1

  • 1Senior Adult Oncology Program, Moffitt Cancer Center, Tampa, Florida, USA.

Gerontology
|June 15, 2023
PubMed
Summary
This summary is machine-generated.

Cancer impacts older adults significantly, with geriatric assessment improving outcomes. Advances in treating leukemia, prostate, breast, and gastrointestinal cancers offer better targeting and reduced toxicity for elderly patients.

Keywords:
Acute myeloid leukemiaBreast cancerColon cancerComprehensive geriatric assessmentEsophageal cancerGeriatric oncologyPancreatic cancerProstate cancerPublic policy

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Area of Science:

  • Geriatric Medicine
  • Oncology
  • Public Health

Background:

  • Cancer is a leading cause of mortality in older adults, with incidence increasing significantly after age seventy.
  • Geriatricians frequently encounter cancer as a clinical challenge in their aging patient population.

Purpose of the Study:

  • To review recent advancements in cancer care relevant to the geriatric community.
  • To highlight the impact of comprehensive geriatric assessment and emerging treatment strategies for older cancer patients.

Main Methods:

  • Review of recent studies and public policy initiatives.
  • Analysis of treatment advancements in specific cancer types (gastrointestinal, breast, acute myeloid leukemia, prostate).

Main Results:

  • Comprehensive geriatric assessment improves outcomes, reducing toxicity and enhancing functional status in older cancer patients.
  • Evidence guides de-escalation of treatment intensity in gastrointestinal and breast cancers.
  • New treatments improve outcomes for acute myeloid leukemia in older adults.
  • Advanced imaging (e.g., PSMA scan) and therapies enhance prostate cancer treatment targeting and reduce toxicity.

Conclusions:

  • Geriatric assessment and management are crucial for optimizing cancer care in older adults.
  • Recent therapeutic and diagnostic innovations offer improved outcomes and reduced side effects for various cancers in the elderly.
  • Global public policy efforts are needed to address the rising cancer burden in aging populations.