Related Experiment Video
Updated: Jul 26, 2025
External Cephalic Version: Is it an Effective and Safe Procedure?
Published on: June 6, 2020
Prediction of cesarean delivery in class III obese nulliparous women: An externally validated model using machine
Massimo Lodi1, Audrey Poterie2, Georgios Exarchakis3
1Obstetrics and Gynaecology Department, Strasbourg University Hospitals, 1 Avenue Molière, 67000 Strasbourg, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS, UMR7104 INSERM U964, Université de Strasbourg, France.
Background:
class III obese women, are at a higher risk of cesarean section during labor, and cesarean section is responsible for increased maternal and neonatal morbidity in this population.
Objective:
the objective of this project was to develop a method with which to quantify cesarean section risk before labor.
Methods:
this is a multicentric retrospective cohort study conducted on 410 nulliparous class III obese pregnant women who attempted vaginal delivery in two French university hospitals. We developed two predictive algorithms (a logistic regression and a random forest models) and assessed performance levels and compared them.
Results:
the logistic regression model found that only initial weight and labor induction were significant in the prediction of unplanned cesarean section. The probability forest was able to predict cesarean section probability using only two pre-labor characteristics: initial weight and labor induction. Its performances were higher and were calculated for a cut-point of 49.5% risk and the results were (with 95% confidence intervals): area under the curve 0.70 (0.62,0.78), accuracy 0.66 (0.58, 0.73), specificity 0.87 (0.77, 0.93), and sensitivity 0.44 (0.32, 0.55).
Conclusions:
this is an innovative and effective approach to predicting unplanned CS risk in this population and could play a role in the choice of a trial of labor versus planned cesarean section. Further studies are needed, especially a prospective clinical trial.
Funding:
French state funds "Plan Investissements d'Avenir" and Agence Nationale de la Recherche.
