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Association between dyslipidemia and asthma in children: a systematic review and multicenter cohort study using a

Ji Eun Lim1, Hye Min Kim1, Ju Hee Kim1,2

  • 1Department of Pediatrics, Kandong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Clinical and Experimental Pediatrics
|June 15, 2023
PubMed

Insights

High total cholesterol (TC) levels in children may increase their risk of developing asthma. This study found a significant association between elevated TC and later asthma diagnosis in children under 15.

Area of Science:

  • Pediatric Pulmonology
  • Cardiovascular Health in Children
  • Epidemiology

Background:

  • The link between dyslipidemia and childhood asthma is not well understood.
  • Existing research on dyslipidemia and asthma in children shows inconsistent findings.

Purpose of the Study:

  • To investigate the association between dyslipidemia, specifically total cholesterol (TC) levels, and asthma in pediatric populations.
  • To clarify the relationship between elevated cholesterol and the incidence of asthma in children.

Main Methods:

  • Conducted a systematic literature review of studies on dyslipidemia and childhood asthma (2000-2022).
  • Analyzed electronic health records from a multicenter cohort study (OMOP-CDM) to assess TC levels and asthma risk.
  • Employed Cox proportional hazards models and propensity score matching for robust analysis, including a meta-analysis of hazard ratios.

Main Results:

  • Eleven studies were reviewed, with most being cross-sectional and yielding inconsistent results.
  • A large multicenter cohort analysis (n=117,861) compared high TC (>170 mg/dL) and normal TC (≤170 mg/dL) groups.
  • Meta-analysis revealed a significant association between high TC levels and the subsequent development of asthma in children under 15 (pooled HR, 1.30).

Conclusions:

  • Elevated total cholesterol levels in children appear to be associated with an increased risk of developing asthma.
  • Findings suggest a potential link between lipid profiles and respiratory health in pediatric populations.
Abstract

Keywords:
Childhood asthmaDyslipidemiaHypercholesterolemia

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