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Epidemiology and risk factors for thrombosis in children and newborns: systematic evaluation and meta-analysis

Shuang Song1, Zhuowei Li2, Guozhen Zhao3

  • 1Integrative Medicine Institute, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

BMC Pediatrics
|June 15, 2023
PubMed

Insights

This meta-analysis identified key risk factors for thrombosis in pediatric and neonatal intensive care units. Central venous catheterization, infection/sepsis, mechanical ventilation, and surgery significantly increase thrombosis risk in critically ill children.

Area of Science:

  • Pediatric critical care medicine
  • Neonatal intensive care
  • Vascular medicine
  • Epidemiology

Background:

  • Thrombosis poses a significant health risk to children and neonates.
  • Established risk factors for pediatric and neonatal thrombosis remain incompletely understood.
  • Accurate identification of thrombosis risk factors is crucial for effective clinical management.

Conclusions:

  • Central venous catheterization, surgery, mechanical ventilation, infection/sepsis, gestational age, and respiratory distress are significant risk factors for thrombosis in pediatric and neonatal ICU patients.
  • These identified risk factors can aid clinicians in recognizing high-risk individuals.
  • Findings support the development and implementation of tailored preventive measures to mitigate thrombosis in critically ill children and neonates.
Abstract

Keywords:
EpidemiologyMeta-analysisNewbornsRisk factorsThrombosis

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