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Updated: Jul 26, 2025

Solid Phase Synthesis of a Functionalized Bis-Peptide Using "Safety Catch" Methodology
Published on: May 15, 2012
Novel amino-Li resin for water-based solid-phase peptide synthesis
Christina Uth1, Simon Englert1, Olga Avrutina2
1Sulfotools GmbH, Rüsselsheim am Main, Germany.
Abstract:
We report the first application of a novel amino-Li resin to water-based solid-phase peptide synthesis (SPPS) applying the Smoc-protecting group approach. We demonstrated that it is a suitable support for the sustainable water-based alternative to a classical SPPS approach. The resin possesses good swelling properties in aqueous milieu, provides significant coupling sites, and may be applicable to the synthesis of difficult sequences and aggregation-prone peptides.
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