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Updated: Jul 26, 2025

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes
08:53

Author Spotlight: Advancing Erythropoiesis Research - A Simplified Pipeline for Assessing Hematopoietic Stem Cell Function in Myelodysplastic Syndromes

Published on: January 10, 2025

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Molecular regulatory mechanisms of erythropoiesis and related diseases

Lin Zhu1,2, Chunyu He3, Yuhao Guo4

  • 1Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China.

European Journal of Haematology
|June 15, 2023
PubMed

The metabolism of cells and blood circulation allow for the constant production and destruction of red blood cells. Erythrocyte formation allows red blood cells to regenerate, which is crucial for maintaining the equilibrium of the organism. Erythrocyte formation is a multi-step, intricate process with distinct structural and functional characteristics at each stage. Erythropoiesis is regulated by a number of signaling pathways; malfunctional regulatory mechanisms may result in disease and aberrant erythropoiesis. Therefore, this article focuses on a review of the erythroid formation process, related signaling pathways, and red blood cell lineage diseases.

Keywords:
erythroid disorderserythropoiesismolecular regulation

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