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Can Serum Magnesium Level and Visual Evoked Potentials (P100) be a Predictive in Migraineurs?: Evidence Based Study
Nisha N Shenoy1, Gaurang K Gheewala2, Rakshith Kedambadi3
1Department of Neurology, Kasturba Medical College, Manipal, Karnataka, India.
Neurology India
|June 16, 2023
Summary
Migraine patients exhibit lower serum magnesium levels and altered visual evoked potentials compared to healthy individuals. Reduced magnesium correlates with specific changes in visual evoked potential amplitude, suggesting neuronal hyperexcitability.
Area of Science:
- Neuroscience
- Clinical Neurology
- Biochemistry
Background:
- Migraine is associated with changes in visual evoked potentials (VEPs) and altered intracellular magnesium levels.
- A correlation between magnesium levels and VEPs in migraine patients remains under-investigated.
Purpose of the Study:
- To compare serum magnesium levels in migraineurs versus a healthy control group.
- To investigate the relationship between serum magnesium levels and VEP changes in migraineurs.
Main Methods:
- 80 subjects (40 migraineurs, 40 controls) were enrolled.
- Serum magnesium levels and visual evoked potentials (VEPs) were measured.
- Migraine diagnosis followed International Headache Society criteria.
Main Results:
- Migraineurs had significantly lower serum total magnesium levels (1.79 ± 0.14 mg/dl) than controls (2.10 ± 0.17 mg/dl).
- A negative correlation was found between reduced serum magnesium and the amplitude of P100 in VEPs (P < 0.0001).
Conclusions:
- Reduced serum magnesium and elevated VEP amplitude in migraineurs may indicate neuronal hyperexcitability in optic pathways.
- These findings suggest a potential link between magnesium deficiency and a lower migraine attack threshold.
