Related Experiment Video For CAPA
Updated: Jul 26, 2025
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Optimal control for co-infection with COVID-19-Associated Pulmonary Aspergillosis in ICU patients with environmental
Nandhini Mohankumar1, Lavanya Rajagopal1, Juan J Nieto2
1Department of Mathematics, Coimbatore Institute of Technology, Tamilnadu, India.
Abstract:
In this paper, we propose a mathematical model for COVID-19-Associated Pulmonary Aspergillosis (CAPA) co-infection, that enables the study of relationship between prevention and treatment. The next generation matrix is employed to find the reproduction number. We enhanced the co-infection model by incorporating time-dependent controls as interventions based on Pontryagin's maximum principle in obtaining the necessary conditions for optimal control. Finally, we perform numerical experiments with different control groups to assess the elimination of infection. In numerical results, transmission prevention control, treatment controls, and environmental disinfection control provide the best chance of preventing the spread of diseases more rapidly than any other combination of controls.
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