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Related Experiment Videos

Haemorrhagic shock and encephalopathy.

K J Van Acker, A M Roodhooft, H Van Bever

    European Journal of Pediatrics
    |April 1, 1986
    PubMed
    Summary

    This study describes a rare, fatal disorder in infants involving circulatory collapse, shock, and encephalopathy. Pathogenesis remains unknown, but potential links to trypsin activity and immune system abnormalities are explored.

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    Prediction of nosocomial sepsis in neonates by means of a computer-weighted bedside scoring system (NOSEP score)

    Critical care medicine·2000

    Area of Science:

    • Pediatric critical care medicine
    • Pathology
    • Biochemistry

    Background:

    • Fulminant pediatric disorders present diagnostic challenges.
    • Disseminated Intravascular Coagulation (DIC) can lead to severe complications.

    Observation:

    • Two infants presented with severe circulatory collapse, shock, seizures, coma, DIC, fever, diarrhea, metabolic acidosis, and organ failure.
    • Autopsies revealed widespread hemorrhages and anoxic brain injury, with normal liver and pancreas structures.

    Findings:

    • The infants likely had hemorrhagic shock and encephalopathy, a recently described, often fatal syndrome.
    • No causative agent was identified, suggesting potential heterogeneity.
    • Abnormal immune test results were noted in family members, though their significance is unclear.

    Implications:

    • Hemorrhagic shock and encephalopathy may be underdiagnosed.
    • Further research is needed to elucidate the syndrome's pathogenesis, potentially involving trypsin activity.
    • Understanding this syndrome is crucial for improving diagnosis and management of critical pediatric illnesses.

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