Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

800
Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
800
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

372
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
372
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

506
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
506
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

2.6K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.6K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

315
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
315

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A post-HSCT ocular surface "Window of Opportunity for Pre-emptive ocular treatment" (WinOP) shows early inflammatory activation and an oGVHD-like molecular subset.

The ocular surface·2026
Same author

Large-scale, spatially resolved panoramic CRISPR screening in native tissue environments using Perturb-DBiT.

Nature biotechnology·2026
Same author

Characterization of Isoorientin and Paeoniflorin as Botanical Glucocorticoid Receptor Modulators from White Peony and Chasteberry.

Nutrients·2026
Same author

Perceptions of the educational environment during clinical training among Vietnamese medical students: a cross-sectional study.

BMC medical education·2026
Same author

Lipid Nanoparticle Surface Engineering with Heparosan Polysaccharides for Safe and Effective mRNA Delivery <i>In Vitro</i> and <i>In Vivo</i>.

ACS applied materials & interfaces·2026
Same author

At-Home Sleep Electroencephalography Assessment in Young and Older Adults Using a Novel Wireless Soft Electronics Sleep Monitoring System: Experimental Study.

JMIR formative research·2026
Same journal

Impact of an Artificial Albumin Corona on Surface Charge-Driven Nano-Bio Interactions and Cytotoxicity of Silver Nanoparticles.

ACS omega·2026
Same journal

Structural and Functional Disruption of Thiopurine S‑Methyltransferase by the A80P Variant: A Simulation and Genotyping Study.

ACS omega·2026
Same journal

CRISPR/Cas12a2-Mediated Ultrasensitive Assay for Rapid Detection of H1N1 Influenza Virus RNA.

ACS omega·2026
Same journal

Photocatalytic Treatment of Real Sugar Industry Wastewater Using Lignocellulosic Biomass-Derived Hydrochar/g-CN.

ACS omega·2026
Same journal

Electrochemical Dopamine Biosensor Based on Plant-Derived Peroxidase Immobilized on Titanate Nanowires.

ACS omega·2026
Same journal

Revealing the Effects of Process Parameters on Structural, Thermal, Mechanical, Biodegradation, and Biocompatibility Properties on the Electrospinning of Poly(vinyl alcohol)/Microbial Inulin Nanofibers.

ACS omega·2026
See all related articles

Related Experiment Video

Updated: Jul 26, 2025

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

9.3K

Synergistic Inhibition Guided Fragment-Linking Strategy and Quantitative Structure-Property Relationship Modeling To

Tasneem M Vaid1, Robel Demissie2, Youngjin Kwon2

  • 1Center for Biomolecular Sciences and Department of Pharmaceutical Sciences, University of Illinois at Chicago, 900 S. Ashland Avenue, Chicago, Illinois 60607, United States.

ACS Omega
|June 16, 2023
PubMed
Summary
This summary is machine-generated.

Researchers identified synergistic fragments that enhance colony-stimulating factor-1 receptor (CSF1R) inhibition for asthma therapeutics. These novel compounds show potential for developing inhalable small molecule drugs.

More Related Videos

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
15:04

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

11.0K
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.8K

Related Experiment Videos

Last Updated: Jul 26, 2025

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections
06:57

The WinCF Model - An Inexpensive and Tractable Microcosm of a Mucus Plugged Bronchiole to Study the Microbiology of Lung Infections

Published on: May 8, 2017

9.3K
Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
15:04

Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols

Published on: May 20, 2016

11.0K
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

40.8K

Area of Science:

  • Biochemistry
  • Pharmacology
  • Drug Discovery

Background:

  • The colony-stimulating factor-1 receptor (CSF1R) is a tyrosine-protein kinase and a potential therapeutic target for asthma.
  • Developing effective asthma therapeutics requires identifying novel small molecules with improved efficacy and delivery.

Purpose of the Study:

  • To identify small fragments that synergistically enhance the inhibitory activity of GW2580, a known CSF1R inhibitor.
  • To design and predict the inhalability of next-generation CSF1R inhibitors for asthma treatment.

Main Methods:

  • Fragment libraries were screened in combination with GW2580 using surface plasmon resonance (SPR).
  • Kinase activity assays, computational solvent mapping, molecular docking, and modeling were employed.
  • Quantitative structure-property relationship (QSPR) modeling predicted the inhalability of designed compounds.

Main Results:

  • Thirteen fragments demonstrated specific binding to CSF1R, with some enhancing GW2580's inhibitory activity.
  • Computational studies indicated fragments bind adjacent to the GW2580 site, stabilizing the inhibitor-bound state.
  • Designed compounds showed predicted inhalability, suggesting potential for inhaled therapeutics.

Conclusions:

  • Fragment-lead combination and computational approaches successfully identified synergistic inhibitors of CSF1R.
  • This study provides a foundation for developing novel, inhalable small molecule therapeutics for asthma targeting CSF1R.