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Updated: Jul 26, 2025

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Decrypting the potency of anti-cancer therapeutics by using mass spectrometry to quantify post-translational
Sophie A Herbst1,2, Forest M White1,2
1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.
Abstract:
In a recent issue of Science, Zecha et al.1 present decryptM, an approach aimed at defining the mechanisms of action of anti-cancer therapeutics through systems-level analysis of protein post-translational modifications (PTMs). By using a broad range of concentrations, decryptM generates drug response curves for each detected PTM, enabling identification of drug effects at different therapeutic doses.
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