Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

148
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
148
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

288
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
288
Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Kaplan-Meier Approach01:24

Kaplan-Meier Approach

195
The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
195
Study Design in Statistics01:15

Study Design in Statistics

8.3K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
8.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying treatment-related travel burden and its association with mortality in pediatric cancer: An analysis of state cancer registry data.

Cancer epidemiology·2026
Same author

Polarisome core component FgPea2 regulates FgBoi2-mediated polarized growth, pathogenicity and environmental stress in Fusarium graminearum.

Stress biology·2026
Same author

Genetic diversity analysis and core collection construction of Macadamia spp. from Yunnan using fourfold degenerate SNP sites.

BMC plant biology·2026
Same author

Case Report: Extracorporeal membrane oxygenation in acute coronary syndrome: a rare case of massive left ventricular thrombus.

Frontiers in cardiovascular medicine·2026
Same author

Exploring the Differences in Alkaloids of Fritillariae Thunbergii Bulbus From Different Regions Using Liquid Chromatography-Mass Spectrometry and Chemometrics.

Chemistry & biodiversity·2026
Same author

A comprehensive narrative review of <i>Epimedium</i> and its bioactive compounds in respiratory diseases.

Journal of pharmaceutical analysis·2026

Related Experiment Video

Updated: Jul 26, 2025

Feeding Experimentation Device FED: Construction and Validation of an Open-source Device for Measuring Food Intake in Rodents
09:18

Feeding Experimentation Device FED: Construction and Validation of an Open-source Device for Measuring Food Intake in Rodents

Published on: February 21, 2017

8.2K

Using Controlled Feeding Study for Biomarker Development in Regression Calibration for Disease Association

Cheng Zheng1, Yiwen Zhang2, Ying Huang3

  • 1Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Statistics in Biosciences
|June 16, 2023
PubMed
Summary

New methods using controlled feeding studies can develop dietary biomarkers and estimate diet-disease links. High sodium/potassium intake is linked to increased cardiovascular disease risks.

Keywords:
BiomarkerCardiovascular DiseaseFeeding StudyMeasurement ErrorRegression Calibration

More Related Videos

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

10.8K
Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

12.5K

Related Experiment Videos

Last Updated: Jul 26, 2025

Feeding Experimentation Device FED: Construction and Validation of an Open-source Device for Measuring Food Intake in Rodents
09:18

Feeding Experimentation Device FED: Construction and Validation of an Open-source Device for Measuring Food Intake in Rodents

Published on: February 21, 2017

8.2K
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

10.8K
Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

12.5K

Area of Science:

  • Nutritional epidemiology
  • Biomarker development
  • Chronic disease risk assessment

Background:

  • Accurate dietary intake assessment is crucial for understanding diet-disease relationships.
  • Self-reported dietary data often contains systematic measurement error.
  • Existing regression calibration methods require specific biomarkers, limiting their application.

Purpose of the Study:

  • To propose novel methods for developing dietary biomarkers using controlled feeding studies.
  • To enable estimation of diet-disease associations for a wider range of dietary components.
  • To address limitations of current methods for correcting measurement error in dietary intake data.

Main Methods:

  • Utilizing controlled feeding studies to create and validate new dietary biomarkers.
  • Developing statistical methods for estimating diet-disease associations with corrected dietary data.
  • Deriving asymptotic distribution theory for proposed estimators.
  • Conducting extensive simulations to evaluate estimator performance.

Main Results:

  • The proposed methods allow for biomarker development for numerous dietary components.
  • Controlled feeding studies can effectively inform diet-disease association estimates.
  • Application to Women's Health Initiative data revealed significant associations.
  • A high sodium/potassium ratio was positively associated with cardiovascular disease incidence.

Conclusions:

  • Controlled feeding studies offer a viable approach for developing dietary biomarkers.
  • The new methods improve the accuracy of estimating diet-disease associations.
  • Elevated sodium/potassium intake is a risk factor for various cardiovascular events.