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[Congenital cataract in a cynomolgus monkey]
Jikken Dobutsu. Experimental Animals
|April 1, 1986
Summary
A rare case of bilateral congenital cataract was observed in a newborn cynomolgus monkey. The cataract showed partial resorption and later re-opacity, prompting further genetic investigation.
Area of Science:
- Ophthalmology
- Primatology
- Developmental Biology
Context:
- A cohort of 1,531 newborn cynomolgus monkeys (Macaca fascicularis) underwent ocular examination.
- A rare incidence of bilateral congenital cataract was identified in a single male neonate (0.07%).
Purpose:
- To document and describe a unique case of bilateral congenital cataract in a non-human primate model.
- To observe the natural progression, including resorption and re-opacity, of congenital cataracts.
Summary:
- The affected male infant presented with bilateral white opacities in both eyes, diagnosed as congenital cataracts.
- Initial partial resorption of the opacities allowed for limited fundus visualization by 2-7 weeks of age.
- However, the opacities recurred, significantly obscuring the lens by 10-14 months of age.
Impact:
- This case highlights the potential for spontaneous cataract development and dynamic changes in non-human primates.
- Further breeding studies are warranted to investigate the potential genetic etiology of this specific cataract presentation.
- Provides a potential model for studying congenital cataracts and their management in a primate setting.