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Investigating the effect of Icaritin on hepatocellular carcinoma based on network pharmacology
Zhong Xue1, Fan Zhang1, Shaohua Xu1
1Department of Hepatobiliary and Pancreatic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Abstract:
Hepatocellular carcinoma is one of the cancers that kill people in the global population. Icaritin, a small molecule drug approved by NMPA, has demonstrated potential anti-HCC effects. However, its underlying molecular mechanisms remain unclear. We employed a multi-omics approach in this study, including pharmaco-omics and proteomics, to look into the Icaritin's possible molecular targets and workings in the therapy of HCC. Through pharmaco-omics analysis, we identified ten putative target genes of Icaritin, including FYN. The relationship between Icaritin and these target genes, particularly FYN, was further validated through in vitro and in vivo experiments. The outcomes revealed that Icaritin may exert its anti-HCC effects through modulating the FYN gene, highlighting the importance of multi-omics approaches in drug discovery research. This research gives valuable insights regarding the therapeutic potential of Icaritin against HCC and its possible molecular mechanisms.
Insights
Icaritin shows promise for treating hepatocellular carcinoma (HCC) by targeting the FYN gene. This study utilized multi-omics to uncover Icaritin
Area of Science:
- Oncology
- Pharmacology
- Genomics
Background:
- Hepatocellular carcinoma (HCC) is a significant global health concern.
- Icaritin, an approved drug, exhibits potential anti-HCC activity, but its mechanisms are unknown.
Purpose of the Study:
- To elucidate the molecular mechanisms of Icaritin in HCC therapy.
- To identify Icaritin's molecular targets using a multi-omics approach.
Main Methods:
- Employed a multi-omics strategy, integrating pharmaco-omics and proteomics.
- Validated identified target genes, focusing on FYN, through in vitro and in vivo experiments.
Main Results:
- Identified ten putative target genes for Icaritin via pharmaco-omics.
- Confirmed FYN as a key target gene modulated by Icaritin in HCC.
Conclusions:
- Icaritin exerts anti-HCC effects potentially through modulating the FYN gene.
- Multi-omics approaches are valuable for drug discovery and understanding therapeutic mechanisms.
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