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Updated: Jul 26, 2025
Intra-tracheal Administration of Haemophilus influenzae in Mouse Models to Study Airway Inflammation
Published on: March 2, 2016
Report of Haemophilus Influenzae serotype a intracranial infections in older children
Varvara Probst1, Fadi Shahoud1,2, Aaron Fletcher Osborne1,2
1Department of Pediatrics University of Florida College of Medicine-Jacksonville Jacksonville Florida USA.
Introduction:
Haemophilus influenzae (Hi) is subdivided into typeable (a-f) and non-typeable groups. Hi serotype b (Hib) has historically been one of the important pathogens responsible for invasive infection. However, after widespread Hib vaccination, the emergence of other Hi serotypes, specifically Hi serotype a (Hia), was noted during the last few decades, mostly in children younger than 5 years of age.
Case Presentation:
We present two cases of severe intracranial infections with detected Hia in patients > 5 years of age within a short time frame and within the same geographic area.
Conclusion:
Epidemiological studies and surveillance on Hia-related illnesses in all age groups worldwide are needed to better understand the clinical and epidemiological characteristics of Hia. This can establish a platform to develop a candidate vaccine against Hia that might protect children of all ages.
