Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of cations on nitrate-to-ammonia synthesis over NiO:SnO<sub>2</sub>: insights from differential electrochemical mass spectrometry.

Chemical communications (Cambridge, England)·2026
Same author

STARTER: a stand-alone reconfigurable and translational organ-on-chip platform based on modularity and open design principles.

Lab on a chip·2026
Same author

Accurate Sizing of Monodisperse Microbubble Suspensions by Optical Attenuation Spectroscopy.

Ultrasound in medicine & biology·2025
Same author

Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk.

Molecular omics·2025
Same author

Electrolytic Bubble Coalescence on Hydrophobic Cavity Arrays Determines Departure Radius and Lowers Electrolyte Supersaturation.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Impact of Tungsten Loading on the Activation of Zeolite-Based Catalysts for Methane Dehydroaromatization.

ACS catalysis·2025

Related Experiment Video

Updated: Jul 26, 2025

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging
06:19

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging

Published on: June 9, 2023

1.6K

Low-Variance Surface-Enhanced Raman Spectroscopy Using Confined Gold Nanoparticles over Silicon Nanocones.

Dirk Jonker1, Ketki Srivastava2, Marta Lafuente1

  • 1Mesoscale Chemical Systems, MESA+ Institute, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

ACS Applied Nano Materials
|June 16, 2023
PubMed
Summary

We developed novel gold nanoparticles on silicon nanocones for ultrasensitive SERS detection. These substrates show extremely low signal variation, enhancing their utility in chemical and biological diagnostics.

More Related Videos

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

20.4K
Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids
06:15

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids

Published on: June 16, 2023

1.9K

Related Experiment Videos

Last Updated: Jul 26, 2025

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging
06:19

Author Spotlight: Advancing SERS Technology: Au@Carbon Dot Nanoprobes for Label-Free Analysis and Imaging

Published on: June 9, 2023

1.6K
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

20.4K
Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids
06:15

Author Spotlight: Advancements and Applications in Nanoparticle Synthesis Through Laser Ablation in Liquids

Published on: June 16, 2023

1.9K

Area of Science:

  • Nanotechnology
  • Spectroscopy
  • Materials Science

Background:

  • Surface-enhanced Raman spectroscopy (SERS) is crucial for sensitive analyte detection in diagnostics.
  • SERS relies on localized 'hot spots' within nanostructures for enhanced signal.
  • Existing SERS substrates often suffer from high signal variance.

Purpose of the Study:

  • To develop a new SERS substrate with ultralow variance.
  • To investigate gold nanoparticles supported by silicon nanocones for enhanced SERS performance.
  • To demonstrate the potential of this new substrate for chemical and biological diagnostics.

Main Methods:

  • Fabrication of 67 ± 6 nm gold nanoparticles using discrete rotation glancing angle deposition.
  • Support of nanoparticles on vertically aligned shell-insulated silicon nanocones.
  • Characterization using focused ion beam tomography, EDX, SEM, and reflectance measurements.
  • Evaluation of SERS activity via benzenethiol functionalization and Raman spectroscopy.

Main Results:

  • Achieved a homogeneous analytical enhancement factor of 2.2 ± 0.1 × 10^7.
  • Reported a strikingly low variance of 4% across 400 measurement spots.
  • Demonstrated superior uniformity compared to other lithographically derived SERS assemblies.

Conclusions:

  • Vertically aligned silicon nanocone-supported gold nanoparticles offer ultralow variance SERS.
  • This substrate design significantly enhances the reliability of SERS measurements.
  • The developed SERS substrates hold great promise for diverse diagnostic applications.