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Vertigoheel promotes rodent cognitive performance in multiple memory tests
Kerstin Ott1, Taneli Heikkinen2, Kimmo K Lehtimäki2
1Heel GmbH, Baden-Baden, Germany.
Frontiers in Neuroscience
|June 16, 2023
Summary
Vertigoheel (VH-04) improved cognitive functions like memory in animal models, potentially by preserving brain cell connections. This suggests VH-04 may act as a cognitive enhancer beyond its use for vertigo.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Cognitive impairment is a significant issue in aging and brain disorders.
- Current treatments offer limited long-term benefits.
- Drug repurposing is a promising strategy for novel therapeutics.
Purpose of the Study:
- To investigate the effects of Vertigoheel (VH-04) on cognitive performance.
- To explore the cellular and molecular mechanisms underlying VH-04's activity.
- To assess VH-04's potential as a cognitive enhancer.
Main Methods:
- Behavioral tests in mice and rats (e.g., novel object recognition, fear conditioning, Morris water maze).
- Assessment of cognitive function after scopolamine-induced impairment.
- In vitro studies on primary hippocampal neurons.
- Analysis of synaptophysin mRNA expression in the hippocampus.
Main Results:
- VH-04 improved visual recognition, spatial working, and olfactory memory.
- It enhanced spatial orientation memory in aged rats.
- VH-04 stimulated neurite growth and potentially reversed age-dependent synaptophysin mRNA decrease.
- No significant effects were observed on fear-aggravated or rewarded alternation memory.
Conclusions:
- VH-04 demonstrates potential as a cognitive enhancer.
- It may preserve synaptic integrity in the aging brain.
- Further research could validate VH-04 for cognitive enhancement therapies.
