Cycle of conception endometrial biopsy

Area of Science:

• Reproductive endocrinology
• Gynecologic pathology

Background:

• Luteal phase inadequacy diagnosis and treatment may improve reproductive outcomes.
• Endometrial biopsy in the cycle of conception (COC) is controversial due to potential pregnancy interruption.

Purpose of the Study:

• To evaluate the impact of endometrial biopsy in the cycle of conception (COC) on pregnancy outcomes.
• To determine if COC endometrial biopsy provides predictive information for pregnancy success.

Main Methods:

• Retrospective analysis of 54 women undergoing endometrial biopsy during the cycle of conception (COC).
• Documentation of patient outcomes, including viable births, ectopic pregnancies, and early abortions.

Main Results:

• Eleven of 54 (20%) women did not deliver viable infants.
• No increased incidence of fetal wastage was observed with COC endometrial biopsy.
• Biopsy information yielded no predictive value for ultimate pregnancy outcome.

Conclusions:

• Endometrial biopsy in the cycle of conception (COC) does not appear to increase fetal wastage.
• COC endometrial biopsy provides no useful predictive information regarding pregnancy outcome.
• Recommend avoiding biopsy or using sensitive pregnancy tests during the cycle of conception.