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Updated: Jul 26, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
Squamous Cell Carcinoma Arising in Discoid Lupus Erythematosus of the Nail Unit
Tatiana Mina Yendo1, Tatiana Villas Boas Gabbi1, Marcello Menta Simonsen Nico1
1Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.
Introduction:
Discoid lupus erythematosus can affect periungual tissues leading to onychodystrophy. Squamous cell carcinoma can occur in persistent scars of discoid lupus; this rare occurrence has not yet been reported on the nail unit. Case presentation: we report a case of squamous cell carcinoma occurring on the distal phalanx of the thumb in a patient with longstanding periungual discoid lupus on several fingernails.
Discussion:
Periungual discoid lupus erythematosus is rare. The scars caused by this disease can very rarely develop into squamous cell carcinoma. This is the first report of this occurrence at the periungual tissues.
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