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Lasse Østrup Petersen1, Ida Rosendal Johansen1

  • 1Øre, Næse og Hals-kirurgisk Afsnit, Sønderborg Sygehus.

Ugeskrift for Laeger
|June 16, 2023
PubMed
Summary
This summary is machine-generated.

A bisphosphonate treatment side effect caused osteonecrosis of the external auditory canal in a diabetic patient with multiple myeloma. Stopping the medication and debridement led to bone lesion improvement.

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Area of Science:

  • Otolaryngology
  • Oncology
  • Pharmacology

Background:

  • A 68-year-old woman with diabetes and multiple myeloma presented with right ear pain.
  • Otomicroscopy revealed exposed bone in the external auditory canal, prompting investigation for infection or malignancy.

Observation:

  • Diagnostic workup included wound swabs, biopsies, MRI, and PET-CT to exclude necrotizing external otitis, cholesteatoma, and malignancy.
  • The patient was undergoing bisphosphonate therapy for multiple myeloma.

Findings:

  • Osteonecrosis of the external auditory canal was suspected as a rare side effect of bisphosphonate treatment.
  • The bone lesion demonstrated improvement following local debridement and discontinuation of bisphosphonate therapy.

Implications:

  • This case highlights a rare but significant side effect of bisphosphonate therapy.
  • Awareness of bisphosphonate-induced osteonecrosis is crucial for managing patients with multiple myeloma and concurrent ear symptoms.