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Watching the clock in glioblastoma
Priscilla Chan1, Jeremy N Rich2, Steve A Kay1
1Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Neuro-Oncology
|June 16, 2023
Summary
Glioblastoma (GBM) research reveals the circadian clock
Area of Science:
- Neuro-oncology
- Molecular Biology
- Cancer Research
Background:
- Glioblastoma (GBM) is a prevalent malignant primary brain tumor with poor prognosis.
- Current treatments offer limited survival benefits, necessitating novel therapeutic strategies.
- Emerging research implicates the circadian clock in GBM development and progression.
Approach:
- This review synthesizes current findings on the role of the circadian clock in GBM.
- It examines the function of core clock proteins, BMAL1 and CLOCK, in GBM tumorigenesis.
- The review discusses potential therapeutic strategies targeting the circadian clock for GBM treatment.
Key Points:
- Positive regulators of circadian-controlled transcription, BMAL1 and CLOCK, are highly expressed in GBM.
- BMAL1 and CLOCK promote Glioblastoma Stem Cell (GSC) maintenance.
- These clock proteins contribute to a pro-tumorigenic tumor microenvironment (TME).
Conclusions:
- The circadian clock plays a critical role in GBM biology.
- Targeting core clock proteins presents a promising strategy to augment GBM treatment.
- Leveraging circadian clock mechanisms may lead to improved clinical outcomes for GBM patients.
