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[How Histone Deacetylase 3 Controls Hepcidin Expression and Hepatitis C Virus Replication].
A S Shcherbakova1, S N Kochetkov1, M V Kozlov1,2
1Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
Molekuliarnaia Biologiia
|June 16, 2023
Summary
Histone deacetylases (HDAC) regulate the hepatitis C virus (HCV) response by controlling hepcidin gene (HAMP) expression. This epigenetic interaction impacts iron metabolism during chronic HCV infection.
Area of Science:
- Virology
- Epigenetics
- Hepatology
Background:
- Histone deacetylases (HDAC) play a critical role in regulating cellular responses to Hepatitis C Virus (HCV) infection.
- Chronic HCV infection in liver tissues is associated with reduced hepcidin gene (HAMP) expression, a key regulator of iron export.
- Oxidative stress induced by HCV infection contributes to the downregulation of HAMP expression in hepatocytes.
Conclusions:
- The interplay between HCV, HDAC3, STAT3, and HAMP is crucial for understanding iron metabolism dysregulation in chronic hepatitis C.
- Epigenetic modifications, particularly histone acetylation, are central to the host's response to HCV infection.
- Targeting this epigenetic regulatory circuit may offer novel therapeutic strategies for managing chronic HCV infection and associated liver disease.
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