Hormones and Aging: An Endocrine Society Scientific Statement.
Anne R Cappola1, Richard J Auchus2,3, Ghada El-Hajj Fuleihan4
1Division of Endocrinology, Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
The Journal of Clinical Endocrinology and Metabolism
|June 16, 2023
Summary
Aging affects multiple endocrine systems, including hormone axes and metabolic conditions. This review synthesizes current research on age-related endocrine changes and their management in older adults to guide future health strategies.
Area of Science:
- Gerontology
- Endocrinology
- Metabolic Medicine
Background:
- Aging is associated with significant changes in various endocrine systems.
- Clinical management strategies for age-related endocrine conditions are continually evolving.
- Older adults present unique physiological considerations for endocrine health.
Purpose of the Study:
- To review the current research on age-related changes in key endocrine axes and metabolic conditions.
- To synthesize data on the efficacy and safety of therapies in older individuals.
- To identify scientific gaps and inform future research for improved health outcomes in aging.
Main Methods:
- Comprehensive literature review of endocrine changes in aging.
- Analysis of natural history and observational data in older populations.
- Evaluation of clinical trial data for therapeutic interventions in the elderly.
Main Results:
- Detailed review of growth hormone, adrenal, ovarian, testicular, and thyroid axes.
- Examination of age-related osteoporosis, vitamin D deficiency, type 2 diabetes, and water metabolism.
- Identification of therapeutic options and their evidence base in older adults.
Conclusions:
- Understanding age-associated endocrine conditions is crucial for geriatric health.
- Further research is needed to refine prevention and treatment strategies.
- Optimizing endocrine health in older individuals can enhance overall well-being.
Keywords:
adrenalandrogendiabetesendocrinologyestrogengrowth hormoneosteoporosisthyroidvitamin Dwater metabolismMore Related Videos
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