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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
951
Combinatorial Herbal Extracts Alleviate Alcohol-Induced Hepatic Disorders
Dongyeop Kim1, Sang Wook Kim2, Haykuhi Charchoghlyan2
1Department of Preventive Dentistry, School of Dentistry, Institute of Medical Information Convergence Research, Jeonbuk National University, Jeonju, Republic of Korea.
Plant Foods for Human Nutrition (Dordrecht, Netherlands)
|June 16, 2023
Summary
Combinatorial herbal extracts show promise in managing alcohol-induced liver disease by restoring cellular balance and regulating inflammation and lipid metabolism. These plant-derived compounds offer a novel therapeutic approach for hepatic disorders.
Area of Science:
- Pharmacology
- Hepatology
- Traditional Chinese Medicine
Background:
- Plant-derived compounds have a long history in treating liver disease.
- Single herbal extracts often show limited antioxidant or anti-inflammatory effects.
- Investigating combinatorial herbal extracts for enhanced hepatoprotective activity is warranted.
Purpose of the Study:
- To evaluate the efficacy of sixteen combinatorial herbal extracts in an alcohol-induced liver disease mouse model.
- To identify active constituents and analyze gene expression changes following treatment.
- To assess the impact on liver inflammation and cholesterol profiles.
Main Methods:
- An ethanol-fed mouse model was used to induce hepatic disorders.
- Sixteen herbal combinations containing specific active constituents were tested.
- RNA sequencing was employed to analyze hepatic gene expression profiles.
- Liver tissue and serum cholesterol levels were analyzed.
Main Results:
- Ethanol exposure significantly altered hepatic gene expression, impacting cellular homeostasis.
- Combinatorial herbal extracts repressed the expression of genes associated with liver dysfunction.
- Herbal treatments prevented acute inflammatory responses and normalized cholesterol profiles.
- Key active constituents included daidzin, peonidin-3-glucoside, hesperidin, glycyrrhizin, and phosphatidylcholine.
Conclusions:
- Combinatorial herbal extracts effectively alleviate alcohol-induced hepatic disorders in mice.
- These formulations modulate inflammatory responses and lipid metabolism in the liver.
- Plant-derived compound combinations represent a potential therapeutic strategy for liver disease management.
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