Related Experiment Video
Updated: Jul 26, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
Emerging functions of tissue-resident eosinophils.
Alessandra Gurtner1, Daniel Crepaz1, Isabelle C Arnold1
1Institute of Experimental Immunology, University of Zürich , Zürich, Switzerland.
Eosinophils, often seen as harmful, also regulate body functions. This review explores their diverse roles in tissues, especially the gut, and how environmental signals shape their activity.
Area of Science:
- Immunology
- Cell Biology
- Gastroenterology
Background:
- Eosinophils are traditionally viewed as effector cells causing tissue damage in type 2 immune diseases.
- Emerging evidence highlights their crucial roles in maintaining tissue homeostasis.
- Their functional adaptability suggests context-dependent roles beyond inflammation.
Conclusions:
- Eosinophils possess a broader functional repertoire than previously recognized.
- Their roles extend to modulating tissue homeostasis, particularly in the gut.
- Understanding environmental cues is key to deciphering eosinophil functions in health and disease.
More Related Videos
10:39Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
Published on: April 16, 2019
09:57Flow Cytometric Analysis for Identification of the Innate and Adaptive Immune Cells of Murine Lung
Published on: November 16, 2021
Related Concept Videos
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Immune Surveillance by NK Cells and Phagocytes
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Cells of the Innate Immune Response
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...