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Updated: Jul 26, 2025
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
miRNAs orchestration of cardiovascular diseases - Particular emphasis on diagnosis, and progression
Elsayed G E Elsakka1, Ahmed I Abulsoud2, Hesham A El-Mahdy1
1Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231 Cairo, Egypt.
Abstract:
MicroRNAs (miRNAs; miRs) are small non-coding ribonucleic acids sequences vital in regulating gene expression. They are significant in many biological and pathological processes and are even detectable in various body fluids such as serum, plasma, and urine. Research has demonstrated that the irregularity of miRNA in multiplying cardiac cells is linked to developmental deformities in the heart's structure. It has also shown that miRNAs are crucial in diagnosing and progressing several cardiovascular diseases (CVDs). The review covers the function of miRNAs in the pathophysiology of CVD. Additionally, the review provides an overview of the potential role of miRNAs as disease-specific diagnostic and prognostic biomarkers for human CVD, as well as their biological implications in CVD.
Insights
MicroRNAs (miRNAs) regulate gene expression and are key in heart development and cardiovascular diseases (CVDs). Aberrant miRNAs in cardiac cells signal heart deformities, highlighting their diagnostic and prognostic potential for CVD.
Area of Science:
- Molecular Biology
- Genetics
- Cardiology
Background:
- MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression.
- miRNAs play critical roles in various biological and pathological processes.
- Altered miRNA expression in cardiac cells is associated with congenital heart defects.
Purpose of the Study:
- To review the role of miRNAs in the pathophysiology of cardiovascular diseases (CVDs).
- To explore the potential of miRNAs as diagnostic and prognostic biomarkers for human CVD.
- To discuss the biological implications of miRNAs in the context of CVD.
Main Methods:
- Literature review of scientific articles on miRNAs and cardiovascular diseases.
- Analysis of the function of miRNAs in cardiac cell regulation and disease progression.
- Evaluation of current research on miRNA biomarkers for CVD diagnosis and prognosis.
Main Results:
- miRNAs are crucial regulators of gene expression in cardiac cells.
- Irregular miRNA expression is linked to structural heart deformities.
- miRNAs show promise as specific biomarkers for diagnosing and monitoring CVDs.
Conclusions:
- miRNAs are integral to understanding CVD pathophysiology.
- miRNAs hold significant potential as non-invasive biomarkers for CVD diagnosis and prognosis.
- Further research into miRNA's biological roles can advance CVD management.
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