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Liquid Biopsies: Emerging role and clinical applications in solid tumours
Sandeep Sisodiya1, Vishakha Kasherwal2, Asiya Khan3
1Cellular and Molecular Diagnostics (Molecular Biology Group), ICMR-National Institute of Cancer Prevention and Research, Noida, India; Symbiosis School of Biological Sciences (SSBS), Symbiosis International (Deemed University) (SIU), Pune, India.
Translational Oncology
|June 16, 2023
Summary
Liquid biopsies offer a less invasive alternative to traditional tissue biopsies for cancer diagnosis. This approach aids in early cancer detection, prognosis prediction, and therapeutic development.
Area of Science:
- Oncology
- Biomarker Discovery
- Diagnostic Technologies
Background:
- Late cancer detection and imprecise diagnostics hinder effective prevention and management.
- Traditional tissue biopsies are invasive, costly, painful, and sometimes inaccessible.
- Biomarker discovery at pre-invasive stages is crucial for early diagnosis and improved outcomes.
Purpose of the Study:
- To review the significance of liquid biopsies in managing solid malignancies.
- To summarize the role of liquid biopsies in diagnosis, prognosis, and therapeutic development.
- To discuss challenges and future perspectives of liquid biopsy technology.
Main Methods:
- Literature review focusing on liquid biopsy applications in oncology.
- Analysis of current diagnostic challenges and the potential of non-invasive methods.
- Exploration of biomarker identification for early diagnosis and targeted therapies.
Main Results:
- Liquid biopsies present a promising non-invasive or minimally invasive approach.
- They are being developed for early cancer diagnosis and identifying targeted therapeutics.
- The review highlights their importance in diagnosis, prognosis prediction, and treatment development.
Conclusions:
- Liquid biopsies are a significant tool for improving cancer management.
- Further research and development are needed to overcome existing challenges.
- The future of oncology diagnostics and therapeutics is likely to involve liquid biopsy advancements.
