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Cerebral perfusion in type 2 diabetes mellitus: A preliminary study with MR perfusion
İbrahim İlik1, Harun Arslan2, Adem Yokuş2
1Van Training and Research Hospital, Department of Radiology, Van, Turkey.
Background:
Type 2 diabetes mellitus (T2DM) is associated with altered cerebral vasoreactivity, cognitive impairment, and functional decline. Magnetic Resonance (MR) perfusion can be used to assess cerebral blood flow (CBF). The aim of this study is to analyze the association between diabetes mellitus and cerebral perfusion.
Methods:
The study included 52 patients diagnosed with T2DM and 39 healthy individuals. The diabetic patients were classified into three groups (PRP: proliferative retinopathy, NPRP: non-proliferative retinopathy, Non-RP: non-retinopathy DM). The rCBF measurements of cortical gray matter and thalami were carried out using the region of interest. Reference quantitative measurements were performed from ipsilateral white matter.
Results:
The comparison between the T2DM group and the control group revealed that rCBF values of bilateral frontal lobes, cingulate gyrus, medial temporal lobe, thalami and right occipital lobe were measured to be significantly lower in the T2DM group (p < 0.05). No significant difference was detected between the two groups in terms of rCBF values of the left occipital lobe and anterior aspect of the left temporal lobe (p > 0.05). The rCBF values were lower in the anterior aspect of the right temporal lobe and the difference showed borderline statistical significance (p = 0.058). No significant difference was detected regarding mean rCBF values measured in the regions of cerebral hemispheres among the three patient groups with T2DM (p˃0.05).
Conclusion:
Regional hypoperfusion was encountered in most of the lobes in the T2DM group when compared with the healthy group. However, in terms of rCBF values, there was no significant difference among the three groups with T2DM.
Insights
Type 2 diabetes mellitus (T2DM) is linked to reduced cerebral blood flow (CBF) in multiple brain regions. This study found significantly lower CBF in T2DM patients compared to healthy individuals, indicating potential hypoperfusion.
Area of Science:
- Neurology
- Endocrinology
- Radiology
Background:
- Type 2 diabetes mellitus (T2DM) is associated with neurological complications, including impaired cerebral vasoreactivity and cognitive decline.
- Cerebral blood flow (CBF) alterations are implicated in T2DM-related brain dysfunction.
- Magnetic Resonance (MR) perfusion imaging offers a method to quantify CBF.
Purpose of the Study:
- To investigate the association between Type 2 diabetes mellitus and cerebral perfusion.
- To compare regional cerebral blood flow (rCBF) in T2DM patients and healthy controls.
Main Methods:
- The study included 52 patients with T2DM and 39 healthy controls.
- T2DM patients were categorized based on retinopathy status (proliferative, non-proliferative, non-retinopathy).
- Regional CBF (rCBF) was measured using MR perfusion imaging, focusing on cortical gray matter and thalami, with white matter as reference.
Main Results:
- T2DM patients exhibited significantly lower rCBF in bilateral frontal lobes, cingulate gyrus, medial temporal lobe, thalami, and the right occipital lobe compared to controls (p < 0.05).
- No significant differences in rCBF were found in the left occipital lobe or anterior left temporal lobe between groups (p > 0.05).
- rCBF in the anterior right temporal lobe showed borderline statistical significance for reduction in T2DM patients (p = 0.058).
Conclusions:
- Regional hypoperfusion is prevalent in most brain lobes of individuals with T2DM compared to healthy subjects.
- No significant differences in rCBF were observed among the different retinopathy subgroups within the T2DM cohort.
