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Updated: Jul 26, 2025

Lumican Extraction from Amniotic Membrane and Determination of its Storage Temperature
Published on: October 14, 2022
The versatile roles of lumican in eye diseases: A review
Mei-Chi Tsui1, Hsin-Yu Liu2, Hsiao-Sang Chu2
1Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; Department of Ophthalmology, An Nan Hospital, China Medical University, Tainan, Taiwan.
Abstract:
Lumican is a keratan sulfate proteoglycan that belongs to the small leucine-rich proteoglycan family. Research has lifted the veil on the versatile roles of lumican in the pathogenesis of eye diseases. Lumican has pivotal roles in the maintenance of physiological tissue homogenesis and is often upregulated in pathological conditions, e.g., fibrosis, scar tissue formation in injured tissues, persistent inflammatory responses and immune anomaly, etc. Herein, we will review literature regarding the role of lumican in pathogenesis of inherited congenital and acquired eye diseases, e.g., cornea dystrophy, cataract, glaucoma and chorioretinal diseases, etc.
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