Association between ambient air pollutant interaction with kidney function in a large Taiwanese population study

The associations and interactions between kidney function and other air pollutants remain poorly defined. Therefore, the aim of this study was to evaluate associations among air pollutants, including particulate matter (PM) with a diameter ≤ 2.5 μm (PM_2.5), PM₁₀ (PM with a diameter ≤ 10 μm), carbon monoxide (CO), nitrogen oxide (NO), nitrogen oxides (NO_x), sulfur dioxide (SO₂), and ozone (O₃) with kidney function, and explore interactions among these air pollutants on kidney function. We used the Taiwan Air Quality Monitoring and Taiwan Biobank databases to derive data on community-dwelling individuals in Taiwan and daily air pollution levels, respectively. We enrolled 26,032 participants. Multivariable analysis showed that high levels of PM_2.5, PM₁₀, O₃ (all p < 0.001), and SO₂ (p = 0.001) and low levels of CO, NO (both p < 0.001), and NO_x (p = 0.047) were significantly correlated with low estimated glomerular filtration rate (eGFR). With regard to negative effects, the interactions between PM_2.5 and PM₁₀ (p < 0.001), PM_2.5 and PM₁₀ (p < 0.001), PM_2.5 and SO₂, PM₁₀ and O₃ (both p = 0.025), PM₁₀ and SO₂ (p = 0.001), and O₃ and SO₂ (p < 0.001) on eGFR were significantly negatively. High PM₁₀, PM_2.5, O₃, and SO₂ were associated with a low eGFR, whereas high CO, NO, and NO_x were associated with a high eGFR. Furthermore, negative interactions between PM_2.5 and PM₁₀, O₃ and SO₂, PM₁₀ and O₃, PM_2.5 and SO₂, and PM₁₀ and SO₂ on eGFR were observed. The findings of this study have important implications for public health and environmental policy. Specifically, the results of this study may be useful in individuals and organizations to take action to reduce air pollution and promote public health.