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H-type hypertension is a risk factor for chronic total coronary artery occlusion: a cross-sectional study from

Kaiyong Xiao1, Zhe Xv2, Yuling Xv3

  • 1Department of Cardiology, Guangyuan Central Hospital, 16 Jingxiangzi, Lizhou District, Guangyuan, 628017, Sichuan, China. keyea1@126.com.

BMC Cardiovascular Disorders
|June 16, 2023
PubMed

Insights

H-type hypertension, a condition combining high blood pressure and elevated homocysteine, significantly increases the risk of chronic total coronary occlusion (CTO). This finding highlights a crucial link between these cardiovascular risk factors.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Vascular Medicine

Background:

  • Chronic total coronary occlusion (CTO) represents a complex challenge in percutaneous coronary intervention.
  • Hypertension and hyperhomocysteinemia (HHCY) are known synergistic risk factors for cardiovascular events.
  • The specific association between H-type hypertension and CTO has not been clearly established.

Purpose of the Study:

  • To investigate the potential association between H-type hypertension and the occurrence of CTO.
  • To assess the predictive accuracy of H-type hypertension for CTO in a Chinese population.

Main Methods:

  • A cross-sectional study involving 1446 individuals from southwest China.
  • CTO defined as complete coronary artery occlusion >3 months; H-type hypertension defined as hypertension with homocysteine ≥15 µmol/L.
  • Multivariate logistic regression and ROC curve analysis were employed.

Main Results:

  • 397 individuals had CTO and 545 had H-type hypertension.
  • H-type hypertension was independently associated with a 2.3-fold increased odds of CTO (OR 2.3, 95% CI 1.01-5.26).
  • The area under the ROC curve for CTO prediction by H-type hypertension was 0.685.

Conclusions:

  • H-type hypertension is significantly associated with the development of CTO in southwest China.
  • Individuals with H-type hypertension face a higher risk of CTO compared to those with isolated HHCY or hypertension.
Abstract

Keywords:
Chronic total coronary occlusionCoronary artery diseaseCoronary occlusionH-type hypertensionHomocysteineHyperhomocysteinemia

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