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High FAAP24 expression reveals poor prognosis and an immunosuppressive microenvironment shaping in AML
Xiebing Bao1,2, Jingyun Chi3, Yiwei Zhu4
1National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Cancer Cell International
|June 16, 2023
Summary
FAAP24 is upregulated in acute myeloid leukemia (AML), correlating with poor prognosis and an immunosuppressive tumor microenvironment. This DNA repair protein shows potential as a prognostic biomarker in AML.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- FAAP24 is crucial for DNA damage repair within the Fanconi anemia pathway.
- Its role in acute myeloid leukemia (AML) prognosis and immune infiltration is not well understood.
Purpose of the Study:
- To investigate FAAP24 expression, immune infiltration, prognostic value, and biological function in AML.
- To validate findings in the Beat AML cohort.
Main Methods:
- Utilized TCGA, TARGET, GTEx, and GEPIA2 for expression and prognostic analysis.
- Developed and validated a nomogram for AML prognosis.
- Explored functional enrichment and immunological features using GO/KEGG, ssGSEA, GSVA, and xCell.
- Conducted drug sensitivity analysis and in vitro validation.
Main Results:
- FAAP24 is upregulated in AML and associated with poor prognosis.
- FAAP24 is involved in DNA damage repair and cell cycle pathways.
- It promotes an immunosuppressive tumor microenvironment in AML.
- High FAAP24 expression correlates with resistance to chelerythrine.
Conclusions:
- FAAP24 serves as a potential prognostic biomarker in AML.
- FAAP24 exhibits immunomodulatory functions in AML progression.
