Related Experiment Video

Updated: May 13, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 18, 2013

Transit of pharmaceutical dosage forms through the small intestine

S S Davis, J G Hardy, J W Fara

    Gut
    |August 1, 1986
    PubMed

    More Related Videos

    An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment08:59

    An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

    Published on: December 3, 2020

    Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates04:40

    Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates

    Published on: October 4, 2024

    Related Concept Videos

    Routes of Drug Administration: Enteral01:18

    Routes of Drug Administration: Enteral

    Medications can be administered through the enteral route using liquids, capsules, or tablets.
    Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
    Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
    Drug Absorption Mechanism: Passive Membrane Transport01:23

    Drug Absorption Mechanism: Passive Membrane Transport

    Passive transport is a method of drug absorption where small, lipid-soluble drugs can move across the cell membrane. This movement happens along the concentration gradient, which is a natural flow from higher to lower concentration areas. The speed at which the drug moves is directly related to its lipid–water partition coefficient. This means that the more a drug dissolves in lipids, the faster it diffuses or spreads throughout the body. It is important to note that most drugs are either weak...
    Drug Absorption: Overview01:17

    Drug Absorption: Overview

    The process of drug absorption signifies the transition of a drug from its site of administration into the plasma. This process is influenced by various factors, including the route of administration, the anatomy of the absorption site, the mechanism of absorption, gut motility, and the drug's physicochemical properties.
    When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI) tract.
    Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

    Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

    Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
    However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
    Factors Influencing Drug Absorption: Anatomical Parameters01:23

    Factors Influencing Drug Absorption: Anatomical Parameters

    Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
    Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

    Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

    Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...