Wrapping dynamics and critical conditions for active nonspherical nanoparticle uptake

The cellular uptake of self-propelled nonspherical nanoparticles (NPs) or viruses by cell membrane is crucial in many biological processes, but its universal dynamics have yet to be elucidated. In this study, using the Onsager variational principle, we obtain a general wrapping equation for nonspherical self-propelled nanoparticles. Two analytical critical conditions are theoretically found, indicating a continuous full uptake for prolate particles and a snapthrough full uptake for oblate particles. They precisely capture the full uptake critical boundaries in the phase diagrams numerically constructed in terms of active force, aspect ratio, adhesion energy density, and membrane tension. It is found that enhancing activity (active force), reducing effective dynamic viscosity, increasing adhesion energy density, and decreasing membrane tension can significantly improve the wrapping efficiency of the self-propelled nonspherical nanoparticles. These results give a panoramic view of the uptake dynamics of active nonspherical nanoparticles, and may offer instructions for designing an effective active NP-based vehicle for controlled drug delivery.