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Targeting m6A binding protein YTHDFs for cancer therapy
Weikun Zhang1, Tingting Wu1, Yuejiao Zhang1
1Jiang Su Key Laboratory of Drug Design and Optimization and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Bioorganic & Medicinal Chemistry
|June 17, 2023
Summary
N6-methyladenosine (m6A) modification is crucial for gene regulation. YT521-B homology domain family (YTHDF) proteins play key roles in cancer, and their inhibition is a promising therapeutic strategy.
Area of Science:
- Molecular Biology
- Epigenetics
- Oncology
Background:
- N6-methyladenosine (m6A) is the most prevalent mRNA modification in mammals.
- m6A dynamics are regulated by "writers", "readers", and "erasers".
- YT521-B homology domain family (YTHDF) proteins (YTHDF1-3) are key m6A "readers".
Purpose of the Study:
- To review the structural characteristics of YTHDF proteins.
- To elucidate the mechanisms by which YTHDFs regulate mRNA.
- To summarize the role of YTHDF proteins in human cancers and potential inhibition strategies.
Main Methods:
- Literature review of structural and functional studies on YTHDF proteins.
- Analysis of research on m6A modification and YTHDFs in various bioprocesses.
- Synthesis of findings on YTHDFs' involvement in tumorigenesis.
Main Results:
- YTHDF proteins exhibit distinct structural features enabling m6A binding.
- YTHDFs modulate gene expression through various mechanisms.
- YTHDF proteins are implicated in multiple stages of cancer development and progression.
Conclusions:
- Understanding YTHDF structure and function is critical for deciphering m6A regulation.
- YTHDF proteins represent significant targets for cancer therapy.
- Inhibition of YTHDFs holds potential for novel anti-cancer strategies.
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