Impact of the gut microbiota on angiotensin Ⅱ-related disorders and its mechanisms

Area of Science:

• Cardiovascular Science
• Microbiome Research
• Endocrinology

Background:

• The renin-angiotensin system (RAS), primarily through Angiotensin II (Ang II), influences inflammation, diabetes, hypertension, and organ damage.
• Gut microbiota dysbiosis is increasingly linked to cardiovascular diseases, metabolic disorders, and chronic inflammatory conditions.
• Emerging evidence indicates Ang II can disrupt intestinal flora, exacerbating disease progression.

Purpose of the Study:

• To explore the intricate relationship between gut microbiota, their metabolites, and Ang II-mediated disease progression.
• To elucidate the mechanisms underlying gut microbiota involvement in Ang II-related pathologies.
• To review potential therapeutic strategies targeting the gut microbiota for RAS-associated disorders.

Main Methods:

• Literature review focusing on studies investigating RAS, gut microbiota, and related diseases.
• Analysis of current research on Ang II's impact on intestinal flora.
• Synthesis of proposed mechanisms linking gut dysbiosis and Ang II signaling.

Main Results:

• Ang II can induce gut microbial imbalance, contributing to disease severity.
• Angiotensin converting enzyme 2 (ACE2) plays a protective role by mitigating Ang II effects and modulating gut microbiota.
• The precise mechanisms connecting gut microbiota characteristics to specific disease pathologies remain under investigation.

Conclusions:

• The gut microbiota and its metabolites significantly interact with the RAS, influencing the development and progression of various diseases.
• Understanding these complex interactions is crucial for developing novel therapeutic approaches.
• Targeting the gut microbiota presents a promising avenue for managing Ang II-related disorders.