Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

55.4K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
55.4K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

303
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
303
Decision Making: P-value Method01:09

Decision Making: P-value Method

5.5K
The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of a salsa dance intervention in young people with mild to moderately severe depressive symptoms.

Psychological medicine·2026
Same author

Pharmacokinetics and pharmacodynamics of orally administered S-ketamine in healthy participants.

Journal of psychopharmacology (Oxford, England)·2026
Same author

Sustained pharmacodynamic effects of S-ketamine on cortical excitability and resting-state brain activity: A randomized, placebo-controlled trial.

British journal of clinical pharmacology·2026
Same author

The effect of acute angiotensin receptor blockade on subjective and biological markers of stress response.

Psychoneuroendocrinology·2026
Same author

Effects of acute ebselen add-on treatment on resting state function connectivity in depressed patients with inadequate response to antidepressants.

Scientific reports·2026
Same author

Effects on hippocampal activity following novel 5-HT4 receptor agonism in unmedicated patients with depression: the RESTAND study.

Translational psychiatry·2026

Related Experiment Video

Updated: Jul 26, 2025

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

9.8K

Pramipexole Enhances Reward Learning by Preserving Value Estimates.

Don Chamith Halahakoon1, Alexander Kaltenboeck2, Marieke Martens3

  • 1Department of Psychiatry, University of Oxford, Oxford, United Kingdom; Oxford Health National Health Service Foundation Trust, Warneford Hospital, Oxford, United Kingdom.

Biological Psychiatry
|June 17, 2023
PubMed
Summary

Pramipexole, a dopamine agonist, improves reward learning by preserving value estimates, suggesting a mechanism for its antidepressant effects. This study clarifies how the drug enhances learning in healthy volunteers.

Keywords:
DepressionDopamineLearningPramipexoleReinforcementRewardfMRI

More Related Videos

Pavlovian Conditioned Approach Training in Rats
06:57

Pavlovian Conditioned Approach Training in Rats

Published on: February 4, 2016

11.0K
Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
08:29

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Published on: June 7, 2018

11.6K

Related Experiment Videos

Last Updated: Jul 26, 2025

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
08:05

A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers

Published on: January 5, 2018

9.8K
Pavlovian Conditioned Approach Training in Rats
06:57

Pavlovian Conditioned Approach Training in Rats

Published on: February 4, 2016

11.0K
Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm
08:29

Reinstatement of Drug-seeking in Mice Using the Conditioned Place Preference Paradigm

Published on: June 7, 2018

11.6K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Computational Psychiatry

Background:

  • Dopamine D2-like agonists are potential depression treatments, possibly by enhancing reward learning.
  • The precise mechanisms of this enhancement remain unclear.
  • Reinforcement learning models propose increased reward sensitivity, inverse decision-temperature, or decreased value decay.

Purpose of the Study:

  • To investigate the effects of the dopamine D2-like agonist pramipexole on reward learning mechanisms.
  • To differentiate between candidate reinforcement learning mechanisms using fMRI.

Main Methods:

  • Double-blind, placebo-controlled study with 40 healthy volunteers.
  • 2 weeks of pramipexole (1 mg/day) or placebo.
  • Probabilistic instrumental learning task and fMRI to assess reward learning, expectation, and prediction errors.

Main Results:

  • Pramipexole improved choice accuracy in reward conditions.
  • Increased BOLD response in orbital frontal cortex during win expectation.
  • Decreased BOLD response to reward prediction errors in ventromedial prefrontal cortex.

Conclusions:

  • Pramipexole enhances reward learning by reducing value decay, preserving learned values.
  • This mechanism offers a plausible explanation for pramipexole's antidepressant potential.