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Molecular determinants of protein evolvability

Karol Buda1, Charlotte M Miton1, Xingyu Cara Fan1

  • 1Michael Smith Laboratories, University of British Columbia, Vancouver, Canada.

Trends in Biochemical Sciences
|June 17, 2023
PubMed
Summary

Protein evolvability, crucial for life, depends on initial states. Understanding molecular determinants and genetic factors offers insights into predicting successful evolutionary pathways for proteins.

Keywords:
enzyme promiscuityevolvabilityfunctional heterogeneitymolecular ensemblesprotein evolutionstability

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