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Partial mastectomy: pathologic findings and prognosis.

R H Lash, T W Bauer, R E Hermann

    Human Pathology
    |August 1, 1986
    PubMed
    Summary
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    Identifying key breast cancer features like lymph node metastasis, mitotic rate, and nuclear atypia can help select patients for partial mastectomy and predict recurrence risk. This aids in personalized treatment decisions for better survival outcomes.

    Area of Science:

    • Oncology
    • Surgical Pathology

    Background:

    • Partial mastectomy is a primary treatment for breast cancer.
    • Adjuvant therapy is typically administered after disease recurrence.

    Purpose of the Study:

    • To identify clinical and pathologic features predicting outcomes in patients undergoing partial mastectomy.
    • To determine factors associated with tumor recurrence and mortality.

    Main Methods:

    • Review of 130 patients treated with partial mastectomy for breast cancer.
    • Follow-up duration ranged from 57 to 128 months (mean 85 months).
    • Univariate and multivariate analyses performed on clinical and pathologic data, including infiltrating ductal carcinoma subgroup.

    Main Results:

    • Lymph node metastasis, high mitotic rate, and nuclear atypia independently correlated with poor survival and/or recurrence.

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  • Combinations of these features further differentiated patient outcomes.
  • Prognostic significance confirmed in infiltrating ductal cancer subgroup.

    • Conclusions:

    • Pathologic features like lymph node metastasis, mitotic rate, and nuclear atypia are significant predictors of breast cancer recurrence and survival.
    • These findings can guide patient selection for partial mastectomy.
    • Identification of high-risk patients can inform decisions regarding adjuvant therapy.