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Related Experiment Video

Updated: Jul 26, 2025

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
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Oral amyloidosis: an update.

F-S Pontes1, G-B Ferreira, F-P Fonseca

  • 1Department of Oral Pathology João de Barros Barreto University Hospital Mundurucus Street, nº 4487, Zip Code 66073-000, Guamá Belém, Pará, Brazil harp@ufpa.br.

Medicina Oral, Patologia Oral Y Cirugia Bucal
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Summary
This summary is machine-generated.

Amyloidosis, a disease of abnormal protein deposition, most commonly affects the tongue in the oral cavity. Systemic amyloidosis, particularly with multiple myeloma, indicates a poorer prognosis.

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Area of Science:

  • Oral pathology
  • Systemic diseases
  • Proteinopathies

Background:

  • Amyloidosis involves progressive abnormal protein deposition in any organ.
  • Oral amyloidosis frequently impacts the tongue, causing macroglossia.
  • Diagnosis requires biopsy, and systemic involvement must be investigated.

Approach:

  • Systematic review of existing literature.
  • Electronic database searches and manual scrutiny.

Key Points:

  • 111 studies and 158 individuals were analyzed.
  • Higher prevalence observed in women.
  • Tongue is the most frequently affected oral site.

Conclusions:

  • Systemic amyloidosis, especially when linked to multiple myeloma, presents the worst prognosis.
  • Understanding clinicopathological characteristics aids treatment and prognosis.
  • Further research into oral amyloidosis is warranted.