[18F]FDG-PET-Based Personalized Radiotherapy Dose Prescription
Johannes H A M Kaanders1, Johan Bussink2, Erik H J G Aarntzen3
1Department of Radiation Oncology, Radboud university medical center, Nijmegen, The Netherlands..
Seminars in Radiation Oncology
|June 18, 2023
Summary
2-deoxy-2-[18F]fluoro-D-glucose (FDG) PET imaging is crucial for cancer management, aiding diagnosis and prognosis. This review explores FDG-PET
Area of Science:
- Nuclear Medicine
- Oncology
- Radiotherapy
Background:
- 2'-deoxy-2'-[18F]fluoro-D-glucose (FDG) PET imaging is a cornerstone in managing malignant diseases.
- [18F]FDG-PET is established for diagnosis, treatment planning, follow-up, and prognosis.
- Its role is expanding towards personalized treatment strategies.
Purpose of the Study:
- To review the potential of [18F]FDG-PET for individualized radiotherapy dose prescription.
- To discuss advanced techniques like dose painting and gradient dose prescription.
- To explore [18F]FDG-PET guided response-adapted dose prescription.
Main Methods:
- Review of current literature and clinical applications of [18F]FDG-PET in radiotherapy.
- Analysis of established and emerging techniques for personalized dose delivery.
- Discussion of progress and future expectations across various tumor types.
Main Results:
- [18F]FDG-PET shows significant potential for tailoring radiotherapy doses.
- Techniques like dose painting and gradient dose prescription are advancing.
- [18F]FDG-PET guided adaptive radiotherapy is emerging as a key development.
Conclusions:
- [18F]FDG-PET is pivotal for personalized radiotherapy, enabling precise dose adjustments.
- Continued research and development are expected to enhance treatment individualization.
- This imaging modality promises improved outcomes through tailored radiation oncology.
